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Results reveal which the effects with the benzodiazepine internet site ligands zolpidem, zopiclone, Cl218872, L-655,708 and DMCM were being almost absolutely eliminated in all mutated receptors as many as a one microM focus. The effects of bretazenil, Ro15-1788 or abecarnil have been eliminated in a few, although not all mutated bensedin diazepam 10mg side effects receptors, suggesting which the gamma 2F77I mutation differentially influences the actions of those ligands in different receptor subtypes. On top of that, this point mutation also influences the efficacy of diazepam for boosting GABA-induced chloride flux, suggesting that the amino acid residue gamma 2F77 may also be involved in the transduction from the result of benzodiazepines from binding to gating.

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